Autoimmune Skin Disease
Mostrando 25-36 de 70 artigos, teses e dissertações.
-
25. Estudo dos herpesvirus humanos tipo 6 e tipo 1 e sua inter-relação com o gene TP53 em diferentes condições patologicas / Study of herpes viruses types 6 and type 1 and their relationship with TP53 gene in distinct pathological conditions
Interactions between viruses, the immune system and detoxifying enzymes have been associated to the etiology of many conditions including cancer and various autoimmune diseases. We investigated the role of herpes viruses type 6 (HHV-6) and 1 (HHV-1) and the codon 72 (P72) and codon 47 (S47) variants of exon 4 of TP53, responsible for a diminished antiapoptot
Publicado em: 2007
-
26. Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem)
Endemic pemphigus foliaceus (EPF) is an autoimmune bullous skin disease characterized by acantholysis and antibodies against a desmosomal protein, desmoglein 1. Genetic and environmental factors contribute to development of this multifactorial disease. HLA class II and some cytokine gene polymorphisms are the only genetic markers thus far known to be associa
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-09
-
27. AVALIAÇÃO IMUNOLÓGICA DOS INDIVÍDUOS EXPOSTOS À RADIAÇÃO IONIZANTE DO 137Cs, NO ACIDENTE RADIOATIVO DE GOIÂNIA (BRASIL).
On September 13, 1987, it happened in Goiânia the largest radioactive accident of the western hemisphere. A capsule containing Cesium 137 (137Cs), originating from an unit of radiotherapy, was violated contaminating more than 200 people and taking 4 individuals to death. From the beginning of the accident, the health of the involved individuals started to b
Publicado em: 2006
-
28. Humoral immune response characterization of the type V collagen induced scleroderma experimental model / Caracterização da resposta imune em modelo experimental de esclerodermia induzida por colágeno tipo V
Experimental models for human diseases are of utmost importance, since they allow the study of their pathogenesis and therapeutic approach. In this group we can include the experimental model of collagen V-induced scleroderma, in rabbits, with histological alterations (skin, lung and kidney) similar to those observed in humans. Auto-immune diseases have an u
Publicado em: 2005
-
29. Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases
Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes mellitus and Cronh's disease. Furthermore, our own studies ha
Memórias do Instituto Oswaldo Cruz. Publicado em: 2004-08
-
30. Dermal dendritic cell number correlates with serum autoantibody titers in Brazilian pemphigus foliaceus patients
Pemphigus foliaceus (PF) is an autoimmune bullous disease endemic in Brazil. Since serum IL-12 is increased in patients with PF and Langerhans cells (LC) produce IL-12, we titrated serum autoantibodies by indirect immunofluorescence, and quantified epidermal dendritic cells, known as LC, and dermal dendritic cells (DC). Biopsies of blistering lesions were ob
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
-
31. The autoimmune blistering skin disease bullous pemphigoid. The presence of plasmin/alpha 2-antiplasmin complexes in skin blister fluid indicates plasmin generation in lesional skin.
Plasminogen activators produced locally in the skin have been implicated in blistering skin diseases. To explore whether plasminogen activators convert their substrate plasminogen into plasmin locally in the lesional skin we have analyzed the autoimmune blistering skin disease bullous pemphigoid. Enzyme activity was detected in bullous pemphigoid skin bliste
-
32. Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients.
Pemphigus vulgaris is an autoimmune blistering disease that is induced by binding of antibodies to a 130/85-kD protein complex on epidermal keratinocytes. An in vivo experimental model of this disease was developed by reconstituting severe combined immunodeficiency (SCID) mice with 1-10 x 10(7) PBL from patients with naturally occurring pemphigus vulgaris. O
-
33. Antigen presentation by keratinocytes directs autoimmune skin disease
The antigen-presenting cells that initiate and maintain MHC class II-associated organ-specific autoimmune diseases are poorly defined. We now describe a new T cell antigen receptor (TCR) transgenic (Tg) model of inflammatory skin disease in which keratinocytes activate and are the primary target of autoreactive CD4+ T cells. We previously generated keratin 1
The National Academy of Sciences.
-
34. Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease.
Epiligrin, the major component of human keratinocyte extracellular matrix, serves as the preferred integrin ligand for alpha 3 beta 1 in plasma membranes and focal adhesions, and colocalizes with alpha 6 beta 4 in hemidesmosomes. In human skin, epiligrin is found in the lamina lucida subregion of epidermal basement membrane, where it is thought to be associa
-
35. The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo
Vitiligo is a common depigmenting disorder resulting from the loss of melanocytes in the skin. The pathogenesis of the disease remains obscure, although autoimmune mechanisms are thought to be involved. Indeed, autoantibodies and autoreactive T lymphocytes that target melanocytes have been reported in some vitiligo patients. The objective of this study was t
American Society for Clinical Investigation.
-
36. Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjögren's syndrome.
Cowden disease is an autosomal dominant disorder associated with an increased risk of breast, thyroid, and skin cancer in which germline mutations in a candidate tumour suppressor gene (PTEN) have been identified previously. Sjögren's syndrome is a chronic inflammatory and autoimmune disorder of exocrine glands for which the genetic basis is unknown. This r