Atp Binding Cassette Transporters
Mostrando 1-12 de 152 artigos, teses e dissertações.
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1. Candida albicans Clinical Isolates from a Southwest Brazilian Tertiary Hospital Exhibit MFS-mediated Azole Resistance Profile
Abstract: Candida albicans is the most frequent fungal species that causes infections in humans. Fluconazole is the main antifungal used to treat Candida infections, and its prolonged and indiscriminate use for the last decades are the most established causes which originated resistant strains. Fungal drug resistance is associated to alterations in ERG11 gen
An. Acad. Bras. Ciênc.. Publicado em: 29/07/2019
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2. Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole
The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated THP-1 cells. BZL induced P-gp and MRP2 proteins in a concentration-dependent manner. The increase in mRNA
Mem. Inst. Oswaldo Cruz. Publicado em: 24/10/2016
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3. A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicate
Mem. Inst. Oswaldo Cruz. Publicado em: 28/04/2015
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4. Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti
The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapam
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-11
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5. Efeito de hipolipemiantes sobre a expressão de genes envolvidos no transporte reverso do colesterol / Statin effects on expression of genes involved in reverse cholesterol transport
The efficacy of statins in reducing the risk of coronary events is not completely explained by their effects in decreasing cholesterol low-density lipoprotein (LDL-C). One of their additional effects may result from the change in concentration of high-density lipoprotein (HDL), recognized as atheroprotective, mainly for the role in reverse cholesterol transp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/09/2011
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6. Estudos estruturais e funcionais das enzimas SsuD e SsuE do sistema de transporte do tipo ABC de alcano sulfonatos e da proteína ligadora periplasmática PbP da bactéria Xanthomonas axonopodis pv.citri / Structural and funcional studies of the enzymes SsuD and SsuE from the alkanesulphonate ABC transporter and the periplasmic binding protein (PbP) from Xanthomonas axopodis pv.citri
A captação de sulfato em Escherichia coli é dependente do transportador do tipo ABC (do inglês, ATP Binding Cassete), SbpCysAWD, pertencente a um regulon que envolve 26 genes. Na ausência de sulfato, a bactéria induz a expressão de dois outros transportadores ABC, o de proteínas do sistema de transporte de alcanosulfonatos (SsuABCDE) e de sulfonatos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/01/2011
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7. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves t
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
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8. Frequency of the mdr-1 C>T gene polymorphism in patients with COPD
BACKGROUND AND AIM: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease. METHOD: DNA samples from 41
Clinics. Publicado em: 2010
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9. Molecular monitoring of patients with chronic myeloid leukemia treated with imatinib mesylate and evaluation of treatment resistance mechanisms: mutation of BCR-ABL and expression of MDR1 and BCRP genes / Acompanhamento molecular de pacientes com leucemia mielóide crônica tratados com mesilato de imatinibe e avaliação dos mecanismos de resistência ao tratamento: mutação do gene BCR-ABL e expressão dos genes MDR1 e BCRP
Chronic myeloid leukemia is characterized by t(9;22) translocation. The chimeric gene BCR-ABL encodes a p210BCRABL protein with constitutive tyrosine kinase activity which is directly related to CML pathogenesis. The imatinib mesylate, a tyrosine kinase inhibitor, is the first-choice treatment for patients in chronic phase but some patients show primary resi
Publicado em: 2009
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10. Efeito da atorvastatina sobre a atividade funcional e expressão de transportadores de membrana do tipo ABC e SLC / Effect of atorvastatin on the activity and expression of ABC and SLC membrane transporters.
Os transportadores de membrana do tipo ATP Binding Cassette (ABC) e solute carriers (SLC) regulam a homeostase intracelular de fármacos, modificando a biodisponibilidade e possivelmente a eficácia terapêutica. A variabilidade na resposta a hipolipemiantes, como as vastatinas, tem sido associada a vários fatores genéticos e ambientais. Com a finalidade d
Publicado em: 2008
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11. Identification of citrus expressed sequence tags (ESTs) encoding pleiotropic drug resistance (PDR)-like proteins
Pleiotropic drug resistance (PDR) proteins, a subfamily of the ATP-binding cassette (ABC) transporters, have been recently shown to play a role in plant defense against biotic and abiotic stresses. However, nothing is known about their expression in citrus. To investigate the occurrence of PDR homologues in citrus species, we have surveyed EST sequences from
Genetics and Molecular Biology. Publicado em: 2007
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12. Mechanism of Coupling of Transport to Hydrolysis in Bacterial ATP-Binding Cassette Transporters
American Society for Microbiology.