Asp 49 Phospholipase A2
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom
Abstract Background: Snake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This work aimed at the isolation and functional characterization of a PLA2 isolated from Bothrops jararaca venom, named BJ-PLA2-I. Methods and Results: For its purification, three cons
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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2. Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/01/2017
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3. Pharmacological and partial biochemical characterization of Bmaj-9 isolated from Bothrops marajoensis snake venom
Bmaj-9, a basic PLA2 (13679.33 Da), was isolated from Bothrops marajoensis snake venom through only one chromatographic step in reversed phase HPLC on ¼-Bondapak C-18 column. The amino acid composition showed that Bmaj-9 had a high content of Lys, His, and Arg, typical of a basic PLA2. The sequence of Bmaj-9 contains 124 amino acid residues with a pI value
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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4. Low-level laser therapy decreases local effects induced by myotoxins isolated from Bothrops jararacussu snake venom
The prominent myotoxic effects induced by Bothrops jararacussu crude venom are due, in part, to its polycationic myotoxins, BthTX-I and BthTX-II. Both myotoxins have a phospholipase A2 structure: BthTX-II is an active enzyme Asp-49 PLA2, while BthTX-I is a Lys-49 PLA2 devoid of enzymatic activity. In this study, the effect of low-level laser therapy (LLLT),
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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5. Functional and structural characterization of phospholipase A2 inhibitors from Bothrops jararacussu snake plasma / Caracterização funcional e estrutural de inibidores de fosfolipases A2 isolados do plasma de serpente Bothrops jararacussu
As fosfolipases A2 (PLA2s) de peçonhas de serpentes compreendem um grupo de enzimas de massas moleculares variáveis entre 14.000 e 18.000, e são responsáveis por vários efeitos tóxicos induzidos pela peçonha destes animais, tornando-se necessária a busca por inibidores naturais de PLA2¬s. O presente trabalho propôs a caracterização bioquímica, f
Publicado em: 2009
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6. Caracterização funcional e estrutural de uma fosfolipase A2 ácida isolada do veneno de Bothrops pirajai / Functional and structural characterization of acidic phospholipase A2 isolated from Bothrops pirajai snake venom.
A caracterização proteômica de venenos de serpentes contribui significativamente para o avanço das Ciências na área Biomédica. Várias destas moléculas, utilizadas como instrumentos de investigação de mecanismos celulares e moleculares, estão envolvidas em diversos processos fisiopatológicos e de intoxicação. No entanto, os venenos de serpentes
Publicado em: 2009
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7. Functional and Structural Characterization of an Acidic Toxic Phospholipase A2 from Bothrops moojeni Snake Venom. / Caracterização funcional e estrutural de uma fosfolipase A2 ácida tóxica isolada da peçonha de Bothrops moojeni
As fosfolipases A2 (PLA2s, E.C. 3.1.1.4) pertencem a uma superfamília de enzimas que realizam a clivagem de fosfolipídios da membrana celular em ácidos graxos e lisofosfolipídios, numa reação dependente de cálcio. As PLA2s apresentam um importante papel em várias funções celulares, incluindo manutenção dos fosfolipídios celulares, geração de p
Publicado em: 2009
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8. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008
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9. Physicoquemical and biologic characterization of phospholipase A2 isolated from Bothrops moojeni venom / Caracterização fisico-quimica e biologica de uma fosfolipase A2 isolada do veneno de Bothrops moojeni
Bothrops moojeni é uma espécie de serpente de grande importância devido a sua ampla distribuição na América do Sul e Central além dos quadros clínicos que o veneno causa. Dentre as espécies peçonhentas brasileiras o gênero Bothrops é o mais numeroso e é o que apresenta os maiores índices de notificações relacionados a acidentes ofídicos. Os
Publicado em: 2008
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10. Modulation in pharmacological action of botropics and crotalics PLA2 in presence of an lectin isolated from marine alga Bryothammion triquetrum / Modulação da ação farmacologica de PLA2 botropicas e crotalicas em presença de uma lectina isolada da alga marinha Bryothamnion triquetrum
Lectins are proteins that bind specifically and reversibly to carbohydrates. They are widely distributed among living organisms and show many activities of biological and medical interest. In this work, two isoforms of lectins isolated from the red marine alga Bryothamnion triquetrum were purified by ion exchange followed by reverse phase chromatographies. T
Publicado em: 2007
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11. Purificação e caracterização de uma nova fosfolipase A2 ácida da peçonha de Bothrops pauloensis
Phospholipases A2 (PLA2) is small enzymes that present molecular mass around 15kDa and are found in a variety of biological and cellular fluids as fluid sinovial, macrophages, platelet, pancreatic tissue, among others. The present work describes the purification and chemical, biological and enzymatic characterization of an acidic phospholipase A2 of Bothrops
Publicado em: 2006
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12. PurificaÃÃo e caracterizaÃÃo de uma nova fosfolipase A2 Ãcida da peÃonha de Bothrops pauloensis
Phospholipases A2 (PLA2) is small enzymes that present molecular mass around 15kDa and are found in a variety of biological and cellular fluids as fluid sinovial, macrophages, platelet, pancreatic tissue, among others. The present work describes the purification and chemical, biological and enzymatic characterization of an acidic phospholipase A2 of Bothrops
Publicado em: 2006