X linked neonatal centronuclear/myotubular myopathy: evidence for linkage to Xq28 DNA marker loci.
AUTOR(ES)
Thomas, N S
RESUMO
We have studied the inheritance of several polymorphic Xq27/28 DNA marker loci in two three generation families with the X linked neonatal lethal form of centronuclear/myotubular myopathy (XL MTM). We found complete linkage of XLMTM to all four informative Xq28 markers analysed, with GCP/RCP (Z = 3.876, theta = 0.00), with DXS15 (Z = 3.737, theta = 0.00), with DXS52 (Z = 2.709, theta = 0.00), and with F8C (Z = 1.020, theta = 0.00). In the absence of any observable recombination, we are unable to sublocalise the XLMTM locus further within the Xq28 region. This evidence for an Xq28 localisation may allow us to carry out useful genetic counselling within such families.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1017076Documentos Relacionados
- X linked neonatal myotubular myopathy: one recombination detected with four polymorphic DNA markers from Xq28.
- X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome.
- A linkage study of a large pedigree with X linked centronuclear myopathy.
- A computer programme to calculate risk in X linked disorders using multiple marker loci.
- A Locus for Bilateral Perisylvian Polymicrogyria Maps to Xq28