VIRUS GENOTYPING HEPATITIS B PATIENTS IN THE UNIVERSITY HOSPITAL OF THE UNIVERSITY FEDERAL OF SERGIPE. / GENOTIPAGEM DO VÍRUS DA HEPATITE B EM PACIENTES DO HOSPITAL UNIVERSITÁRIO DA UNIVERSIDADE FEDERAL DE SERGIPE.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

INTRODUCTION: The virus of hepatitis B was classified in eight genotypes that vary with geographic distribution, presenting different clinical manifestations and responses to anti-viral treatment. PURPOSES: This work intends to determine the prevalence of genotypes in Sergipe Brasil and evaluate them according to clinical and histopathological findings. METHODOLOGY: In a transversal search, were evaluated 97 patients, all of them AgHBs chronic porters, with traces of viral replication. From those patients, we got DNAs amplification in 43 samples, that formed the core to genotypical determination. Those were also evaluated on AgHBe positivity, viral load (CV) quantification, aminotransferases (ALT) and histological data. RESULTS: The genotypes A and F, were identified, with 35/43 (81.4%) of genotype A. Twenty Five from 43 patients (58.1%) presented abnormal ALT level, AgHBe negative (23/43 53.5%) and CV below 10.000 copies/ml (20/32 62.5%). In the patients presenting genotype A, 20/32 (62.5%) presented CV below 10,000 copies/ml, but in those with the genotype F, 5/7 (71.4%) presented CV above 10,000 copies/ml (p=0,101). There was no statistic difference between viral genotype and histological findings. CONCLUSION: In Sergipe, the genotypes A and F were found, but predominates the genotype A. Important differences were not found among the genotypes relatively to clinical and laboratorial findings.

ASSUNTO(S)

hepatite b crônica genótipo correlações clínicas medicina chronic b hepatitis genotype clinical correlations

Documentos Relacionados