Variability in innate host immune responses to cryptococcosis

AUTOR(ES)

Garelnabi, Mariam, May, Robin C

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

16/04/2018

RESUMO

Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups.

Documentos Relacionados

• Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo
• Susceptibility to Polyomavirus-Induced Tumors in Inbred Mice: Role of Innate Immune Responses
• Stereotyped and specific gene expression programs in human innate immune responses to bacteria
• Toll Receptors: a Central Element in Innate Immune Responses
• Innate Immune Responses in Children and Adults with Shigellosis