UV derivative spectrophotometric method for determination of estradiol valerate in tablets
AUTOR(ES)
Mendez, Andreas S. L., Deconto, Lislaine, Garcia, Cássia V.
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2010
RESUMO
A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, Δλ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL-1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation.
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