Utilização da triancinolona como agente modulador da resposta inflamatória na cirurgia de músculo extra-ocular em coelhos / Experimental extraocular surgery in rabbits with triamcinolone: outcomes and effects on inflammatory response

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Purpose: To evaluate the efficiency of triamcinolone acetonide (TRI) in limiting the postoperative inflammatory response and scarring following strabismus surgery. Methods: A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular reattachment site was analyzed following superior rectus recession in ten rabbits. One eye had 0,15 cc of triamcinolone acetonide (40mg/cc) applied around the new insertion site and, similarly, 0,15 cc of isotonic saline solution (0,9%) was applied to the fellow eye following the same procedure, thus serving as a control. Fifteen days later, orbital exenteration was performed in five rabbits and the remaining five were exenterated thirty days later. The reattachment site tissues were submitted to qualitative and quantitative histological examinations. In the second stage 16 rabbits were submitted to amplified surgical trauma, after which the aforementioned steps were also carried out. Granuloma total area at the extraocular muscle reattachment sites of control and treated eyes were compared. Results: There was an inhibitory effect of TRI on the inflammatory response of treated eyes as compared to control eyes. Conclusions: TRI was effective in controlling the postoperative inflammatory response in rabbit eyes submitted to traumatic recession of the superior rectus muscle.

ASSUNTO(S)

triamcinolone acetonide cicatrização de feridas estrabismo/cirurgia rabbits strabismus/surgery triancinolona acetonida wound healing coelhos adhesions aderências

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