Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates

AUTOR(ES)

Quiles, M.G., Rocchetti, T.T., Fehlberg, L.C., Kusano, E.J.U., Chebabo, A., Pereira, R.M.G., Gales, A.C., Pignatari, A.C.C.

FONTE

Braz J Med Biol Res

DATA DE PUBLICAÇÃO

05/12/2014

RESUMO

We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (blaNDM-1)-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. blaNDM-1 was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (blaKPC-2) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of blaNDM-1 in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.

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