Unexpected HLA haplotype sharing in dizygotic twin pairs discordant for rheumatoid arthritis.
AUTOR(ES)
Jawaheer, D
RESUMO
Dizygotic twins are generally believed to be no more genetically similar than sibs born from separate pregnancies. In the present study, a panel of 93 dizygotic twin pairs discordant for rheumatoid arthritis were typed for HLA-A, -B, -Cw, and -DR antigens. HLA haplotype sharing identical by descent between the twins showed a trend towards increased sharing of both HLA haplotypes; this increased sharing was statistically significant when the female/female twin pairs were considered separately. In contrast, the pattern of HLA haplotype sharing in sib pairs (n = 128) was consistent with a 1:2:1 ratio of 2, 1, or 0 haplotypes shared. An analysis of 16 normal dizygotic twin pairs was consistent with these results raising the possibility that dizygotic twins in general are genetically more similar at the HLA complex than sibs born from separate pregnancies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1050813Documentos Relacionados
- HLA haplotype sharing by siblings with rheumatoid arthritis: evidence for genetic heterogeneity.
- HLA haplotypes in non-familial rheumatoid arthritis.
- HLA antigens and seronegative rheumatoid arthritis.
- Influence of previous exposure to human parvovirus B19 infection in explaining susceptibility to rheumatoid arthritis: an analysis of disease discordant twin pairs.
- HLA DR antigens and disease expression in rheumatoid arthritis.