Understanding Protein Structure from a Percolation Perspective

AUTOR(ES)

Deb, Dhruba

FONTE

The Biophysical Society

RESUMO

Underlying the unique structures and diverse functions of proteins are a vast range of amino-acid sequences and a highly limited number of folds taken up by the polypeptide backbone. By investigating the role of noncovalent connections at the backbone level and at the detailed side-chain level, we show that these unique structures emerge from interplay between random and selected features. Primarily, the protein structure network formed by these connections shows simple (bond) and higher order (clique) percolation behavior distinctly reminiscent of random network models. However, the clique percolation specific to the side-chain interaction network bears signatures unique to proteins characterized by a larger degree of connectivity than in random networks. These studies reflect some salient features of the manner in which amino acid sequences select the unique structure of proteins from the pool of a limited number of available folds.

Documentos Relacionados

• Understanding the Deliberation Practice in a Controllership from the Performative Judgement Perspective
• Understanding local governance: an international perspective
• Going Beyond Academic Integrity Might Broaden our Understanding of Plagiarism in Science Education: A Perspective from a Study in Brazil
• The contribution of a gender perspective to the understanding of migrants' health
• UNDERSTANDING SOCIAL MEDIA MINDSET OF CONSUMERS: AN INDIAN PERSPECTIVE