Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface

AUTOR(ES)

Red-Horse, Kristy

FONTE

American Society for Clinical Investigation

RESUMO

Trophoblasts, the specialized cells of the placenta, play a major role in implantation and formation of the maternal-fetal interface. Through an unusual differentiation process examined in this review, these fetal cells acquire properties of leukocytes and endothelial cells that enable many of their specialized functions. In recent years a great deal has been learned about the regulatory mechanisms, from transcriptional networks to oxygen tension, which control trophoblast differentiation. The challenge is to turn this information into clinically useful tests for monitoring placental function and, hence, pregnancy outcome.

Documentos Relacionados

• Tobramycin: Maternal-Fetal Pharmacology
• CD1d and invariant NKT cells at the human maternal–fetal interface
• Pregnancy initiation in the rhesus macaque: Towards functional manipulation of the maternal-fetal interface
• Maternal-Fetal Interactions and the Maintenance of Hla Polymorphism
• Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal–fetal interface in the mouse placenta