The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.
AUTOR(ES)
Shieh, H S
RESUMO
A 2:2 complex of proflavine and deoxycytidylyl-3', 5'-guanosine has been crystallized and its structure determined by x-ray crystallography. The two dinucleoside phosphate strands form self complementary duplexes with Watson Crick hydrogen bonds. One proflavin is asymmetrically intercalated between the base pairs and the other is stacked above them. The conformations of the nucleotides are unusual in that one strand has C3',C2'endomixed sugar puckering and the other has C3',C3' endo deoxyribose sugars. These results show that the conformation of the 3'sugar is of secondary importance to the intercalated geometry.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=327244Documentos Relacionados
- The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.
- Analysis of conformational parameters in nucleic acid fragments. IV. Intercalating drug complexes of very short chain oligonucleotides.
- Analysis of conformational parameters in nucleic acid fragments. II. Co-crystal complexes of nucleic acid bases.
- Preparation of covalently linked DNA-RNA hybrids and arabinocytidine containing DNA fragments.
- Mass spectrometric monitoring of solid phase phosphate triester synthesis of DNA fragments.