The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

AUTOR(ES)

Sakaguchi, Shimon

FONTE

American Society for Clinical Investigation

RESUMO

Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway .

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