The influence of pH on the healing-over of mammalian cardiac muscle.

AUTOR(ES)

De Mello, W C

RESUMO

The process of healing-over was followed in trabeculae from the right ventricle of guinea-pigs and in Purkinje fibres from dogs by measuring resting potential and input resistance close to a site of damage. In Ca2+-free bathing solution at pH 6.5 no signs of healing-over were found; at pH 5.5 healing-over was incomplete; at pH 5.0 and 4.0 healing-over occurred promptly. It is concluded that transformation of low-resistance nexus membranes into high-resistance membranes separating the intracellular from the extracellular compartment normally is due to Ca2+, while protons can bring about the same effect under extreme conditions.

Documentos Relacionados

• Healing-over in rat crystalline lens.
• The effects of changes of pH on intracellular calcium transients in mammalian cardiac muscle.
• Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
• The influence of intracellular pH on contraction, relaxation and [Ca2+]i in intact single fibres from mouse muscle.
• The effect of intracellular pH on ATP-dependent potassium channels of frog skeletal muscle.