The evaluation of connective tissue and platelet-rich plasma (PRP) on the periodontal regenegaration in gingival recession : a histomorphometric study in dogs / Avaliação histometrica da associação do plasma rico em plaquetas com o enxerto de tecido conjuntivo subepitelial em retrações gengivais em cães

Fabricia Ferreira Suaid

The aim of this study was to histometrically evaluate the healing process of gingival recessions treated by PRP in combination with subepithelial connective tissue graft (SCTG) and to compare it to that obtained with SCTG alone (Control). Six mongrel dogs were used in the experiment. Gingival recessions (5x7mm) were surgically created and exposed to plaque accumulation for 1 month. Contralateral defects were then randomly assigned to test group or control. Dogs were sacrificed 45 days after healing, and the blocks containing the experimental specimens were processed for histological analysis. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone and defect extension. A superior length of new cementum, statistically significant, was observed in sites treated with PRP (2.18 ± 0.78mm) in comparison with the control (1.19 ± 0.62mm). No statistical differences in any other parameters evaluated were detected. The extension of the sulcular and junctional epithelium was 2.04 ± 0.57 mm for the PRP group and 2.49 ± 0.82mm for the control. The new connective tissue adjacent to the root without cementum formation was 0.29 ± 0.28 mm and 0.23 ± 0.18 mm for the PRP group and control, respectively. Bone formation was ? 0.57 ± 0.95 mm for the PRP group and ? 0.46 ± 1.34mm for the control. Within the limits of this study, it was concluded that PRP in combination with subepithelial connective tissue graft, when compared to the other treatment (control), seems to be more effective in promoting new cementum formation

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