The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder
AUTOR(ES)
Ekmekci, Sümeyye; Küçük, Ülkü; Kaya, Özge; Yörükoğlu, Kutsal
FONTE
Rev. Assoc. Med. Bras.
DATA DE PUBLICAÇÃO
2021-01
RESUMO
SUMMARY OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinoma seen in patients under 40 years of age and tumor microsatellite instability status using immunohistochemistry. METHODS: A total of 50 patients under the age of 40 with urothelial bladder carcinoma from two different centers in the same country were included. Expression of the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2 was analyzed by immunohistochemistry. RESULTS: Age at the time of diagnosis ranged from 17 to 40 years old. Most tumors were non-invasive papillary urothelial carcinoma. Two cases had nuclear loss of MSH-6 and PMS-2. We observed that tumor grade, tumor stage, presence of tumor differentiation, and infiltrative growth pattern of the tumor have significant impact on prognosis, but microsatellite instability does not have an effective role in bladder carcinogenesis in young patients. CONCLUSIONS: Our results indicate that the presence of microsatellite instability is not related to the low tumor grade and stage in urothelial neoplasms in young patients, suggesting that urothelial carcinoma of the bladder in young patients may represent a genetically stable form of neoplasia.
Documentos Relacionados
- Association between human papillomavirus and urothelial carcinoma of the bladder
- The plasmacytoid carcinoma of the bladder: rare variant of aggressive urothelial carcinoma
- Morphometric differences between urothelial cells in voided urine of patients with grade I and grade II bladder tumours.
- Preoperative hydronephrosis predicts adverse pathological features and postoperative survival in patients with high-grade upper tract urothelial carcinoma
- Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis