The Ah Phenotype. Survey of Forty-Eight Rat Strains and Twenty Inbred Mouse Strains
AUTOR(ES)
Nebert, Daniel W.
RESUMO
Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1201803Documentos Relacionados
- REPORT OF FORTY-EIGHT CASES OF MARGINAL BLEPHARITIS TREATED WITH PENICILLIN*
- The eye at birth: measurement of the principal diameters in forty-eight cadavers
- Glucuronidase Phenotypes of Inbred Mouse Strains
- Structural variation of the pseudoautosomal region between and within inbred mouse strains.
- Differentiation and cancer: the conditional autonomy of phenotype.
