Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A

AUTOR(ES)

Santos, Edson dos Anjos dos, Beatriz, Adilson, Lima, Dênis Pires de, Marques, Maria Rita, Leite, Carla Braga

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2009

RESUMO

Inspired by the structure and biological activities of resorcinolic lipids and, particularly cytosporone A- a potent inhibitor of plantule germination and growth, we have performed the synthesis of the analogs 3-heptyl-3-hydroxy-5,7-dimethoxy-2-benzofuran-1(3H)-one (1) and 3-heptyl-3-hydroxy-4,6-dimethoxy-2-benzofuran-1(3H)-one (2). The intermediates and products were submitted to allelopathic test using Lactuca sativa L. seeds. Target compound 1 showed an inhibitory effect on germination and growth of hypocotyl and radicle in milimolar range.

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