Synergistic action of ampicillin and nafcillin against ampicillin-resistant Haemophilus influenzae.
AUTOR(ES)
Yogev, R
RESUMO
Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per ml. Studies with these agents demonstrated synergism against all six strains of H. influenzae type b. Most strains were inhibited by 0.78 microgram of nafcillin plus 0.78 microgram of ampicillin per ml. A child with osteomyelitis caused by H. influenzae type b was successfully treated with a combination of ampicillin and nafcillin. These data suggest that further studies assessing the synergistic effect of this drug combination against H. influenzae type b are warranted.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283809Documentos Relacionados
- Synergistic action of nafcillin and ampicillin against ampicillin-resistant Haemophilus influenzae type b bacteremia and meningitis in infant rats.
- In vitro activities of aztreonam, imipenem, and amoxycillin-clavulanate against ampicillin-resistant Haemophilus influenzae.
- Rapid detection in spinal fluid of beta-lactamase produced by ampicillin-resistant Haemophilus influenzae.
- Beta-Lactamase Activity in Ampicillin-Resistant Haemophilus influenzae
- Characterization of an Ampicillin-Resistant Haemophilus influenzae Type B
