Syndrome in question: antisynthetase syndrome (anti-PL-7)
AUTOR(ES)
Esposito, Ana Cláudia Cavalcante, Gige, Tatiana Cristina, Miot, Hélio Amante
FONTE
An. Bras. Dermatol.
DATA DE PUBLICAÇÃO
2016-10
RESUMO
Abstract: Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies.
