Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
AUTOR(ES)
Virmani, Tuhin
FONTE
Oxford University Press
RESUMO
The speed of synaptic vesicle recycling determines the efficacy of neurotransmission during repetitive stimulation. Synaptotagmins are synaptic C2-domain proteins that are involved in exocytosis, but have also been linked to endocytosis. We now demonstrate that upon expression in transfected neurons, a short splice variant of synaptotagmin 7 that lacks C2-domains accelerates endocytic recycling of synaptic vesicles, whereas a longer splice variant that contains C2-domains decelerates recycling. These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=213769Documentos Relacionados
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