Suicidality with selective serotonin reuptake inhibitors: Valid claim?
AUTOR(ES)
Lapierre, Yvon D.
RESUMO
The red flags raised by the 1990 clinical reports of increased suicidality associated with treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine were followed by anecdotal reports of similar symptoms with other antidepressants of the same class. Recent discussions by Healy have argued in favour of a suicidogenic potential of the SSRIs. This paper reviews the relevant literature addressing the epidemiological data of Western populations and the data accumulated from clinical trial databases in several countries. The evidence currently available does not support the hypothesis that antidepressants or, more specifically, SSRIs cause increased suicidality in patients with depression, nor do they appear to do so in patients treated with these drugs for other reasons.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=193980Documentos Relacionados
- Selective serotonin reuptake inhibitors: THREAD trial may show way forward
- Selective serotonin reuptake inhibitors: Remain useful drugs which need careful monitoring
- Selective serotonin reuptake inhibitors: Evidence base for older antidepressants is shaky too
- Selective serotonin reuptake inhibitors: Placebo washouts inflate antidepressant effects in general practice
- Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials