Stimulation of heme oxygenase in macrophages and liver by endotoxin.
AUTOR(ES)
Gemsa, D
RESUMO
In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by the ingested erythrocyte hemoglobin. Endotoxin neither appeared to injure the erythrocytes, nor did it enhance the rate of erythrophagocytosis. In intact rats, HO activity in both parenchymal and sinusoidal cells of the liver was increased after treatment with endotoxin. It is likely that endotoxin directly stimulates HO activity, a process which may account for the reported rise in bilirubin formation in endotoxin-treated animals. The effect of endotoxin on HO may represent part of the general activation of phagocytic cells by endotoxin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301508Documentos Relacionados
- Role of interleukin-1 in the depression of liver drug metabolism by endotoxin.
- Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin.
- Effects of BCG infection on the susceptibility of mouse macrophages to endotoxin.
- The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.
- Erythrocyte Catabolism by Macrophages In Vitro THE EFFECT OF HYDROCORTISONE ON ERYTHROPHAGOCYTOSIS AND ON THE INDUCTION OF HEME OXYGENASE