Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form
AUTOR(ES)
Behera, Anindita, Moitra, Swapan Kumar, Si, Sudam Chandra, Sankar, Dannana Gowri
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2011
RESUMO
Two sensitive and simple spectrophotmetric methods were developed for determination of Atazanavir Sulfate in capsule dosage form. The first method was based on the oxidative coupling of ATV with 3-Methyl Benzothiazolin-2-one hydrazone (MBTH). The resulting green product had Λmax of 627.3 nm and was stable for 2 h. The second method was based on the reaction between diazotized drug with N-(1-napthyl)ethylenediamine dihydrochloride (NEDA) in neutral medium to yield yellowish orange product which had Λmax of 517.1 nm. The product was stable for 4 h. Both methods were highly reproducible and had been applied to pharmaceutical preparations.
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