Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
AUTOR(ES)
Grangeiro Jr., Severino, Albuquerque, Miracy M., Santana, Davi P., Pimentel, Maria Fernanda, Silva, Reniere H. da, Simões, Simone S.
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2011
RESUMO
The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC.
Documentos Relacionados
- Multivariate spectroscopic determination of the lamivudine-zidovudine association
- Simultaneous Determination of Different Phenolic Compounds Using Electrochemical Biosensor and Multivariate Calibration
- Simultaneous voltammetric determination of dypirone and paracetamol with carbon paste electrode and multivariate calibration methodology
- Simultaneous spectrophotometric determination of ezetimibe and simvastatin in pharmaceutical preparations using chemometric techniques
- Simultaneous Quantitation of Intracellular Zidovudine and Lamivudine Triphosphates in Human Immunodeficiency Virus-Infected Individuals