Severe Schistosomiasis in the Absence of Interleukin-4 (IL-4) Is IL-12 Independent

AUTOR(ES)

Patton, Elisabeth A.

FONTE

American Society for Microbiology

RESUMO

An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 dependent in this system.

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