Serum determination of creatinephosphokinase-isoenzyme MB (CK-MB) enzyme and of troponin I (cTnI) in electrocardiographic normal dogs and in those with ST deviation (elevation or depression) by a chemiluminescent immunometric assay / Dosagem sérica da enzima creatinafosfoquinase-isoenzima MB (CK-MB) e de troponina I (cTnI) de cães eletrocardiograficamente normais e naqueles com desníveis (infra e supra) do segmento ST, utilizando ensaio imunométrico por quimioluminescência

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Although very often in men, hypoxic and ischemic heart diseases are poorly documented in dogs. There are few reports of acute myocardial infarction (AMI) in this species. However, some electrocardiographic findings may suggest myocardium hypoxia/ischemia, like ST segment elevation or depression. In order to investigate myocardial cells injury in poor perfusion conditions, 38 dogs, being 20 with normal electrocardiogram and 18 with ST segment elevation or depression in lead II, at a paper speed of 50 mm/sec and N sensibility (1 mV = 1cm), were included. Serum measurement of creatinephosphokinase isoenzyme MB (CK-MB) enzym and troponin I (cTnI) in normal dogs (group 1) determined reference values (in ng/ml). These values were compared to those obtained in dogs with deviation (group 2), which allowed confirmation or not of myocardial injury. CK-MB mean values obtained from dogs in groups 1 and 2 was 0,54 ng/mL (SD±0,54 ng/mL) and 0,44 ng/mL (SD±1,106), respectively. Mean cTnI values in groups 1 and 2 was 0,16 ng/mL (SD±0,110 ng/mL) and 0,20 ng/mL (SD±0,111 ng/mL) respectively. Three cTnI null values were found in group 1. There was a marked difference concerning to age, being group 1 composed, mainly, by animals ageing under 7 years, on the contrary of group 2. At a significance level of 5%, was significant the relation of CK-MB with age, mass and total creatinephosphokinase (CK-T) in group 1 and with CK-T in group 2. There is no relation, at a significance level of 5%, of cTnI with age, mass, CK-T or serum potassium concentration, for each level of group variable. Both CK-MB and cTnI variables showed no difference, at 5% level, between groups 1 and 2. In conclusion, it is possible to use the human chemiluminescent immunometric assay kit in canine species and that hypoxia/ischemia revealed by ST segment deviation does not mean significant myocardium injury.

ASSUNTO(S)

dogs troponin i st segment ck-mb cães troponina i ck-mb creatinafosfoquinase creatinephosphokinase segmento st

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