Serosal reaction in chronic gastric ulcers: an immunohistochemical and ultrastructural study.
AUTOR(ES)
Pitt, M A
RESUMO
AIM--To study the serosal reaction in gastrectomy specimens with benign chronic peptic ulcers. METHODS--Gastrectomy specimens were fixed in neutral buffered formalin and paraffin wax, and examined using immunohistochemical and ultrastructural techniques. RESULTS--Nine of the 22 (41%) cases examined showed reactive hyperplasia of the serosal cells. The cells were predominantly spindle-shaped and were positive on staining with Cam 5.2, AE1/3 and for vimentin. Eight of nine were also positive for smooth muscle actin and five for desmin. Ultrastructural analysis of these cells suggests that they may be myofibroblastic in nature. CONCLUSIONS--These results support the concept of "multipotential" subserosal cells which may differentiate into surface serosa or, in the reactive state, modulate the thin cytoskeletal filaments and become more myofibroblastic. Particular care should be taken not to confuse these reactive serosal cells with carcinoma or smooth muscle tumours in endoscopic biopsy specimens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=502451Documentos Relacionados
- Solitary fibrous tumour of the pleura: an ultrastructural and immunohistochemical study.
- The innervation of the splenic capsule in the guinea pig: an immunohistochemical and ultrastructural study.
- Chronic leg ulcers: an underestimated problem in primary health care among elderly patients.
- Chronic ulcers: considerations about contaminant flora, infection and antimicrobial treatment
- Retinal and epiretinal glia--an immunohistochemical study.