Sequence logos: a new way to display consensus sequences.
AUTOR(ES)
Schneider, T D
RESUMO
A graphical method is presented for displaying the patterns in a set of aligned sequences. The characters representing the sequence are stacked on top of each other for each position in the aligned sequences. The height of each letter is made proportional to its frequency, and the letters are sorted so the most common one is on top. The height of the entire stack is then adjusted to signify the information content of the sequences at that position. From these 'sequence logos', one can determine not only the consensus sequence but also the relative frequency of bases and the information content (measured in bits) at every position in a site or sequence. The logo displays both significant residues and subtle sequence patterns.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=332411Documentos Relacionados
- Sequence walkers: a graphical method to display how binding proteins interact with DNA or RNA sequences.
- Para além do lógos: a peste de Atenas na obra de Tucídides
- Critical comparison of consensus methods for molecular sequences.
- Na aproximação de mythos e logos: a compreensão sobre o modo de ser dos homens
- A comparison of expressed sequence tags (ESTs) to human genomic sequences.