Sensitivity and specificity of single and combined tumour markers in the diagnosis of leptomeningeal metastasis from breast cancer.
AUTOR(ES)
Twijnstra, A
RESUMO
The clinical efficacy of four laboratory tests in detecting leptomeningeal metastases in 57 patients with breast carcinoma was assessed. The sensitivity and specificity of beta-glucuronidase, beta 2-microglobulin, carcinoembryonic antigen and lactate dehydrogenase in cerebrospinal fluid were determined. As a single test beta-glucuronidase was the most sensitive (93%) and specific (93%) for discriminating between leptomeningeal metastases and other CNS metastases from breast cancer. Lactate dehydrogenase was the next most useful marker. Both beta 2-microglobulin and carcinoembryonic antigen had a sensitivity of 60%. More specific results were achieved by combining beta-glucuronidase and lactate dehydrogenase. CSF beta-glucuronidase may be useful by itself and in combination with lactate dehydrogenase in the detection of leptomeningeal metastases from breast carcinoma.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1029072Documentos Relacionados
- Endobronchial metastasis in breast cancer.
- Delay in diagnosis of breast cancer.
- Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo
- Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer.
- Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells
