Selective and non-extractive spectrophotometric determination of cefdinir in formulations based on donor-acceptor complex formation
AUTOR(ES)
Singh, Babita K., Parwate, Dilip V., Srivastava, Seema, Shukla, Sudhir. K.
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2010
RESUMO
Cefdinir has broad spectrum of activity and high prescription rates, hence its counterfeiting seems imminent. We have proposed a simple, fast, selective and non-extractive spectrophotometric method for the content assay of cefdinir in formulations. The method is based on complexation of cefdinir and Fe under reducing condition in a buffered medium (pH 11) to form a magenta colored donor-acceptor complex (λ max = 550 nm; apparent molar absorptivity = 3720 L mol-1 cm-1). No other cephalosporins, penicillins and common excipients interfere under the test conditions. The Beer's law is followed in the concentration range 8-160 µg mL-1.
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