Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
AUTOR(ES)
Sartori, Debora Sarzi; Almeida, Antônia Larangeira de; Oliveira, Gabriel Santana Pereira de; Almeida Jr, Hiram Larangeira de
FONTE
Anais Brasileiros de Dermatologia
DATA DE PUBLICAÇÃO
2022
RESUMO
Abstract Panitumumab is a monoclonal antibody against the epidermal growth factor receptor used in metastatic colorectal cancer; in addition to tumor cells, it acts on epidermal keratinocytes and on the outer root sheath and presents skin toxicity in up to 90% of cases. A scanning electron microscope was used to examine the eyelashes and hairs of a 65-year-old patient with eyelash trichomegaly, curly hair, and paronychia undergoing treatment with panitumumab. Grooving in the hair shafts were identified, which were more evident in the eyelashes. Similar to oral epidermal growth factor inhibitors (erlotinib and gefitinib), panitumumab can cause acquired pili canaliculi.
