Role for macrophage migration inhibitory factor in asthma
AUTOR(ES)
Mizue, Y.
FONTE
National Academy of Sciences
RESUMO
Macrophage migration inhibitory factor (MIF) is an immunologic regulator that is expressed in inflammatory and autoimmune disorders. We investigated MIF's role in asthma using genetic approaches in a mouse model and in a cohort of asthma patients. Mice genetically deficient in MIF that were primed and aerosol-challenged with ovalbumin showed less pulmonary inflammation and lower airway hyperresponsiveness than genetically matched, wild-type controls. MIF deficiency also resulted in lower titers of specific IgE, IgG1, and IgG2a, and decreased pulmonary, TH2 cytokine levels. IL-5 concentrations were lower and corresponded to decreased eosinophil numbers in bronchoalveolar lavage fluid. T cell studies also showed a lower level of antigen-specific responses in MIF-KO versus wild-type mice. In an analysis of 151 white patients with mild, moderate, or severe asthma (Global Initiative for Asthma criteria), a significant association was found between mild asthma and the low-expression, 5-CATT MIF allele. Pharmacologic inhibition of MIF may be beneficial and could be guided by the MIF genotype of affected individuals.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1242335Documentos Relacionados
- Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.
- An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
- Role of Macrophage Migration Inhibitory Factor in Otitis Media with Effusion in Adults
- Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium
- Migration Inhibitory Factor and Macrophage Bactericidal Function