Rietveld Method in the Analysis of Polymorphism in Mebendazole Tablets Acquired in Brazil’s Drugstores
AUTOR(ES)
Salvi, Simone T. B., Antonio, Selma G., Ferreira, Fabio F., Paiva-Santos, Carlos O.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2015-09
RESUMO
Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A.
Documentos Relacionados
- Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
- Tariff discrimination on Brazil's soluble coffee: an economic analysis
- Internal configuration of maxillary molars in a subpopulation of Brazil’s Northeast region: A CBCT analysis
- Regional development and engineering education: an analysis of Brazil’s micro-regional scenario
- Mineralogical of a highly-weathered soil by the Rietveld Method
