Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.
AUTOR(ES)
Harrison, D G
RESUMO
Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=442458Documentos Relacionados
- Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.
- Endothelium-dependent relaxation is independent of arachidonic acid release.
- Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.
- Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.
- Role of membrane potential in endothelium-dependent relaxation of guinea-pig coronary arterial smooth muscle.