Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
AUTOR(ES)
Liberati, Nicole T.
FONTE
National Academy of Sciences
RESUMO
The p38 mitogen-activated protein kinase pathway regulates innate immune responses in evolutionarily diverse species. We have previously shown that the Caenorhabditis elegans p38 mitogen-activated protein kinase, PMK-1, functions in an innate immune response pathway that mediates resistance to a variety of microbial pathogens. Here, we show that tir-1, a gene encoding a highly conserved Toll/IL-1 resistance (TIR) domain protein, is also required for C. elegans resistance to microbial pathogens. RNA interference inactivation of tir-1 resulted in enhanced susceptibility to killing by pathogens and correspondingly diminished PMK-1 phosphorylation. Unlike all known TIR-domain adapter proteins, overexpression of the human TIR-1 homologue, SARM, in mammalian cells was not sufficient to induce expression of NF-κB or IRF3-dependent reporter genes that are activated by Toll-like receptor signaling. These data reveal the involvement of a previously uncharacterized, evolutionarily conserved TIR domain protein in innate immunity that is functionally distinct from other known TIR domain signaling adapters.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=404090Documentos Relacionados
- RME-8, a Conserved J-Domain Protein, Is Required for Endocytosis in Caenorhabditis elegans
- A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling
- Functional Requirement for Histone Deacetylase 1 in Caenorhabditis elegans Gonadogenesis
- Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for Epithelial Integrity
- Differences in protein expression associated with ivermectin resistance in Caenorhabditis elegans