Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.
AUTOR(ES)
Gregory, S A
RESUMO
Tissue factor is the cellular receptor and cofactor for plasma factor VIIa which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362351Documentos Relacionados
- Cultured human endothelial cells generate tissue factor in response to endotoxin.
- Expression of tissue factor procoagulant activity: regulation by cytosolic calcium.
- The role of tumor necrosis factor and nitric oxide in the acute cardiovascular response to endotoxin.
- Lymphoid procoagulant response to bacterial endotoxin in the rat.
- Airway constrictor response to cotton bract extracts in the absence of endotoxin.