Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.
AUTOR(ES)
Janeway, C A
RESUMO
The ability of thymus-derived lymphocytes (T cells) from BALB/c mice to recognize the individually specific antigenic determinants (idiotypes) of BALB/c myeloma proteins was tested. Spleen cells from donor mice immunized with a given myeloma protein greatly augmented the response of hapten-specific bone marrow-derived, thymus-independent lymphocytes (cells) to a hapten conjugate of the immunizing myeloma protein. This helper effect was specific for the myeloma protein idiotype; responses to hapten conjugates of similar myeloma proteins, bearing different idiotypic determinants, were not augmented by these spleen cells. That the helper cell is a T cell was shown by its marked sensitivity to cytolysis with an isoantiserum specific for T cells (anti-Thy-1-2) and complement. The discrimination between idiotypes by such T cells is roughly comparable to that of the antibody produced by the donors of the helper cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432757Documentos Relacionados
- Release of colony-stimulating activity from thymus-derived lymphocytes.
- Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes.
- Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.
- Antigenic polypeptide fragments of a receptor related to the Fab fragment of human immunoglobulin from thymus-derived lymphocytes.
- Suppressor thymus-derived lymphocytes in fungal infection.