Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein
AUTOR(ES)
Krall, Rebecca
FONTE
American Society for Microbiology
RESUMO
Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=101576Documentos Relacionados
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