ProgramaÃÃo pela desnutriÃÃo perinatal do controle serotoninÃrgico da liberaÃÃo do Ãxido nÃtrico por macrÃfagos alveolares em ratos adultos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Restriction on nutritional feeding has long-term consequences on the functioning of neuroimmune systems. Receivers and serotonin transporter present in alveolar macrophages (AM) are related to its operation. In the article "Perinatal malnutrition programs sustainable alterations in nitric oxide production and cell viability in activated macrophages of the adult rat," perinatal effects of malnutrition on in vitro release of nitric oxide (RNO) were analyzed in AM in adult rats. The rats malnourished (M) had retarded growth, confirmed by the low weight at weaning, persisting up to 90 days of life. The M also had lower total number of cells and AM in bronchoalveolar lavage. The RNO by AM and viability of these cells was lower in M. In the article, "Perinatal malnutrition programs sustained alterations in nitric oxide release by activated macrophages in response to fluoxetine in adult rats", in adults, nourished or malnourished in the perinatal phase, was evaluated the RNO by AM in response to fluoxetine in different concentrations and time, and also in response to receptor agonists, 5-HT1A and 5- HT1B. In the presence of fluoxetine, the RNO control by AM was minor, a response related to dose, but not the time. The addition of agonists did not interfere in the production of NO by AM in control. The RNO by AM-M was lower in all times examined. The RNO has not changed in the presence of fluoxetine or agonists by AM of M. In conclusion, nutritional manipulation in the perinatal period seems to interfere with the programming of the function of macrophages and affects their serotoninergic regulation, passed in the adult body

ASSUNTO(S)

ratos malnutrition programming programaÃÃo serotonina nutricao Ãxido nÃtrico desnutriÃÃo nitric oxide rat serotonin macrÃfago alveolar alveolar macrophage

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