Presence of the bcr/abl rearrangement in a patient with chronic neutrophilic leukaemia.
AUTOR(ES)
Christopoulos, C
RESUMO
An 83 year old women presented with a myeloproliferative disorder involving the myeloid and megakaryocytic lines, and characterised by mature neutrophil leucocytosis. There was a high/normal neutrophil alkaline phosphatase activity and absence of the Philadelphia chromosome, features compatible with a diagnosis of chronic neutrophilic leukaemia (CNL). Southern blot analysis of the patient's DNA revealed the presence of the bcr/abl rearrangement. Combined with a previous report of detection of Ph1 chromosome in long term bone marrow cultures in a patient with CNL, this finding suggests that the bcr/abl hybrid gene might occasionally result in a myeloproliferative disorder with a phenotype closely resembling that of CNL.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=499653Documentos Relacionados
- Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
- Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms
- BCR/ABL induces multiple abnormalities of cytoskeletal function.
- Biological consequences of the BCR/ABL fusion gene in humans and mice.
- Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.