Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished, inducible nitric oxide synthase-deficient mice with schistosomiasis mansoni infection

AUTOR(ES)

Ramos, Renata P, Costa, Vlaudia MA, Melo, Camila F, Souza, Valdênia MO, Malagueño, Elizabeth, Coutinho, Eridan M, Abath, Frederico G C, Montenegro, Silvia ML

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2006-10

RESUMO

Schistosoma mansoni infected C57Bl/6 inducible nitric oxide synthase (iNOS)-deficient and non-deficient malnourished mice, both fed a balanced controlled diet were studied. Interleukins, IL-4 and IL-10 responses to soluble egg antigens (SEA) 90 days after infection, were determined. Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. We are currently investigating the biological significance of these findings.

Documentos Relacionados

• Inducible Nitric Oxide Synthase-Deficient Mice Develop Enhanced Type 1 Cytokine-Associated Cellular and Humoral Immune Responses after Vaccination with Attenuated Schistosoma mansoni Cercariae but Display Partially Reduced Resistance
• Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy
• Allergic lung responses are increased in prostaglandin H synthase–deficient mice
• Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
• Impaired liver regeneration in inducible nitric oxide synthasedeficient mice