Plasma Lipoproteins in Liver Disease: I. Immunologically Distinct Low-Density Lipoproteins in Patients with Biliary Obstruction*

AUTOR(ES)

Switzer, Sam

RESUMO

Sera from patients with extrahepatic biliary obstruction were found to have an abnormal lipoprotein (obstructive lipoprotein) which failed to react with antibodies to normal lipoproteins of d < 1.063. Preparations of this abnormal lipoprotein made by a combination of immunoprecipitation and multiple polyanion precipitations revealed a high content of free cholesterol (26%) and phospholipids (61%) but only trace amounts of cholesterol esters and triglycerides. Protein content varied from 13% to a corrected low of 5% when ultracentrifugation was also performed. Amino acid analyses of the latter preparations resembled that of lipoproteins of d < 1.006.

Documentos Relacionados

• Why are low-density lipoproteins atherogenic?
• Structure of human plasma low-density lipoproteins: molecular organization of the central core.
• High-density lipoprotein, low-density lipoprotein, and coronary heart disease.
• Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease
• Phosphorylcholine-Dependent Cross-Reactivity between Dental Plaque Bacteria and Oxidized Low-Density Lipoproteins