Pharmacokinetic and therapeutic trial of sultamicillin in acute sinusitis.
AUTOR(ES)
Jones, S
RESUMO
Sultamicillin, an antibiotic combining ampicillin and the beta-lactamase inhibitor sulbactam, was administered to 13 patients diagnosed as having acute sinusitis. Specimens from sinus were obtained for all 13 patients by transantral puncture. Pharmacokinetics, bacteriology, and therapeutic efficacy were assessed. Eighty-five percent (11 of 13) were cured; two treatment failures were subsequently shown to have chronic (rather than acute) sinusitis during surgical exploration. Diarrhea was frequently encountered, and Clostridium difficile-associated enteritis was documented for one patient. Beta-lactamase-producing organisms were not encountered in this study; however, this study provides impetus for further controlled clinical trials.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180339Documentos Relacionados
- Comparison of cyclacillin and amoxicillin for therapy for acute maxillary sinusitis.
- Histoplasma capsulatum sinusitis.
- Comparative effectiveness and safety of cefdinir and amoxicillin-clavulanate in treatment of acute community-acquired bacterial sinusitis. Cefdinir Sinusitis Study Group.
- Practical approach to diagnosing and treating sinusitis.
- Comparison of the nasal bacterial floras in two groups of healthy subjects and in patients with acute maxillary sinusitis.