Perspectivas de novos tratamentos para o carcinoma tireoidiano avançado
AUTOR(ES)
Rodrigues, Aluízio
FONTE
Revista do Colégio Brasileiro de Cirurgiões
DATA DE PUBLICAÇÃO
2006-06
RESUMO
In the treatment of thyroid cancer, the greatest problem existis in tumors that continue to grow or express recurrences, despite surgical, radioidine or t4 supressive therapies. Improved knowledge of the molecular biology of tumors showed that elevated expression of oncogeneses, uncontrolled ativation of tyrosine cinase receptors and their signaling pathways, and inibition of programmed apoptosis are all important factors in the origin and evolution of tumors and their metastasis. The development of therapies targeted against especific molecular deregulation envolved in tumor progression is now been evaluated, with sucess, in various types of cancer. In thyroid cancer, target therapies using drugs, antibodies, genes, and small molecules are in development in preclinical studies and show a potential role in the managment of thyroid cancer, in the future. In this review, some of these studies are discussed.
Documentos Relacionados
- Terapias locorregionais para o tratamento do carcinoma hepatocelular localmente avançado
- Limitações e avanços em novos tratamentos e perspectivas futuras na cegueira corneal
- Tratamentos farmacológicos para o transtorno de ansiedade social: existem novos parâmetros na atualidade?
- Comparação dos tratamentos do carcinoma espinocelular avançado do esofago pela teleterapia exclusiva e pela teleterapia associada à braquiterapia
- Perspectivas sobre o acesso aos tratamentos de fertilidade em Portugal