Penetration of pefloxacin into cerebrospinal fluid of patients with meningitis.
AUTOR(ES)
Wolff, M
RESUMO
We evaluated the diffusion of pefloxacin into the cerebrospinal fluid (CSF) in 15 patients with bacterial meningitis or ventriculitis, 14 of whom were treated with other antibiotics. Three doses of pefloxacin were administered at 12-h intervals to 11 patients intravenously and to 4 patients orally. Individual doses were 7.5 mg/kg in seven patients and 15 mg/kg in eight patients. Plasma and CSF levels were determined by a high-performance liquid chromatographic assay. The concentrations of pefloxacin in CSF were measured 2 h after the third intravenous dose and 4 h after the third oral dose. In patients receiving 7.5 mg/kg, peak levels in plasma ranged from 6.8 to 16 micrograms/ml, and trough levels were from 2 to 7.5 micrograms/ml. Concentrations in CSF ranged from 2.4 to 9 micrograms/ml. In patients receiving 15 mg/kg, peak levels in plasma ranged from 14 to 18.6 micrograms/ml, and trough levels were from 4 to 13.2 micrograms/ml. Concentrations in CSF ranged from 6.5 to 13 micrograms/ml. These preliminary data indicate that pefloxacin diffuses well into the CSF of patients with inflamed meninges.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=176153Documentos Relacionados
- Moxalactam penetration into cerebrospinal fluid in patients with bacterial meningitis.
- Cefoxitin penetration into cerebrospinal fluid in patients with purulent meningitis.
- Penetration of aztreonam into cerebrospinal fluid of patients with bacterial meningitis.
- Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis.
- Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis.
