Patterns of gene expression that characterize the colonic mucosa in patients at genetic risk for colonic cancer.

AUTOR(ES)

Augenlicht, L H

RESUMO

We have used a computer-driven scanning and image-processing system to identify a panel of 30 cDNA clones whose pattern of expression in individual biopsy specimens distinguishes the flat, normal-appearing colonic mucosa of patients in two genetic groups at high risk for development of colorectal cancer from that of normal colonic mucosa in low-risk individuals. The two high-risk groups, familial adenomatous polyposis and hereditary nonpolyposis colon cancer, are indistinguishable based on the pattern of expression of the 30 selected clones. This suggests that the extensive pleiotropic effects of the inherited loci, which may play an important role in the mechanism of increased risk and early onset of the disease, are similar in these populations.

Documentos Relacionados

• Absence of pepsinogen A3 gene expression in the gastric mucosa of patients with gastric cancer.
• Mucosal abnormalities at the anastomosis site in patients who have had intestinal resection for colonic cancer.
• The search for risk factors in breast cancer.
• Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.
• National patterns of care for pancreatic cancer. Results of a survey by the Commission on Cancer.