Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

AUTOR(ES)

Calistro Neto, José Pedro, Torres, Rômulo da Costa, Gonçalves, Giovanna Maria, Silva, Leopoldo Muniz da, Domingues, Maria Aparecida Custódio, Módolo, Norma Sueli Pinheiro, Barros, Guilherme Antonio Moreira de

FONTE

Acta Cir. Bras.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.

Documentos Relacionados

• Effect of ischemia preconditioning on renal ischemia/reperfusion injury in rats
• Protective Effects of Geraniol on Long Term Renal Ischemia/Reperfusion Injury in Rats
• Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury
• Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia/reperfusion injury in rats
• Grape seed protects cholestatic rats liver from ischemia/reperfusion injury