Optimization of tablets containing a high dose of spray-dried plant extract: A technical note
AUTOR(ES)
Lira Soares, Luiz Alberto
FONTE
Springer-Verlag
RESUMO
Optimization of CSD and CMC-Na in tablet formulations containing a high dose of SDE fromM ilicifolia was performed by central composite design (CCD) and response surface methodology (RSM). The study demonstrated that CSD affected mainly the hardness and friability, while CMC-Na modified the disintegration times. The optimum formula for minimum disintegration time and friability, and maximum crushing strength, was found to contain 1.2% (wt/wt) of CSD and 5.0% (wt/wt) of CMC-Na. At these conditions, the tablet shows a crushing strength of 107.9 N, a friability of 0.56% (wt/wt), and a maximum disintegration time of 6.8 minutes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750379Documentos Relacionados
- Development of granules from Phyllanthus niruri spray-dried extract
- Studies on spray-dried mixtures of chitosan and hydrolyzed gelatin as tablet binder: A technical note
- Dry granulation and compression of spray-dried plant extracts
- Pharmaceutical development of tablets containing a spray-dried optimized extract from Lippia origanoides H. B. K.: influence of excipients and toxicological assessment
- Eudragit E as excipient for production of granules and tablets from phyllanthus niruri L spray-dried extract